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KMID : 0366919990110000255
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Sungkyun Pharmceutical Journal
1999 Volume.11 No. 0 p.255 ~ p.257
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Structure-Activity Relationship Study of Asiatic Acid Derivatives Against Beta Amyloid (Aβ)-induced Neurotoxicity
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Jew, Sang-sup
Yoo, Chi-hyoung/Lim, Doo-yeon/Kim, Heeman/Mook-Jung, Inhee/Jung, Min Whan/Choi, Heesung
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Abstract
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Abstract-8 Semi-synthetic derivatives of asiatic acid were prepared and their protective effect against Aβ-induced neurotoxicity was evaluated. Among them, asiatic acid (2), and 4, 16 showed 97, 92 and 87% of protective effect, respectively. ⓒ 2000 Elsevier Science Ltd. All rights reserved.
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